Zonisamide, Topiramate, and Levetiracetam

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Zonisamide, Topiramate, and Levetiracetam

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Zonisamide, Topiramate, and Levetiracetam: Efficacy and Neuropsychological Effects in Alcohol Use Disorders

The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment. Zonisamide is a structurally related anticonvulsant that is a promising agent for the treatment of AD and may have greater tolerability than topiramate. This study evaluated the effects of zonisamide (400 mg/d) on alcohol con...

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Effect of topiramate and zonisamide on fMRI cognitive networks

OBJECTIVE To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched...

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ژورنال

عنوان ژورنال: Journal of Clinical Psychopharmacology

سال: 2015

ISSN: 0271-0749

DOI: 10.1097/jcp.0000000000000246